Experimental research

Includes bibliographical references

Citrus maxima is known to contain different bioactive chemical constituents, among which is citric acid, used in the pharmaceutical industry and recognized for its antioxidant qualities. The citric acid present in the Citrus maxima has limited research in regard to the incorporation of the citric acid in a liquid dosage form. The purpose of the study is to formulate a physically stable liquid dosage form with the use of citric acid isolated from the fruit Citrus maxima. The juice from the pulp of the fruit, from which the citric acid was isolated, reveals a 19.76% yield of citric acid. The suha juice was diluted (distilled water) and neutralized (NaOH) with a 7.00 to 7.20 pH level. The sample underwent various heating processes to crystallize. FTIR analysis indicated the presence of citric acid, and impurity tests showed moisture content (32.71% to 37.70%). Concentration from titration of citric acid (0.031 to 0.040 M). The stability of the liquid dosage form incorporated with the isolated citric acid revealed an acidic pH, stable temperature, and physical properties. The thin chromatography analysis using solvent (distilled water, acetic acid, and butanol) for the detection of citric acid and identification of RF value (0.95 to 0.98), revealing the presence of citric acid. The pH (4.05-4.18) of the formulation at various temperatures for one month shows its stability over an extended period. In conclusion, the citric acid isolated from the Citrus maxima fruit helps stabilize the formulated liquid dosage.