02718nam a22002657a 4500 OSt 20261110142554.0 261110s2025 |||||||| |||| 00| 0 eng d T PHAR F67 2025 Abril, John Elcid L. Formulation of anti-inflammatory gel from celery (apium graveolens) leaves and stalk extract tested through egg albumin denaturation assay / John Elcid L. Abril, Reign Deniela C. Batutay, Leilord M. Beltran, Athena Brittany Cates E. Comodas, and Alyssa Mae B. Navarro. EAC Cavite : School of Pharmacy, 2025. xiii, 109 pages ; 28 cm. rdacontent text rdamedia unmediated rdacarrier volume Experimental research Includes bibliographical references Inflammation is a biological response to harmful stimuli that aims to eliminate pathogens or injury. This study show the effect of celery in an inflammation in the form of gel. The properties found in celery, such as flavonoids and antioxidants, have shown effectiveness in reducing inflammation associated with inflammatory conditions. The toxicity of the celery's extract was assessed using the Brine Shrimp Lethality Assay, it showed a dose-dependent effect, at concentrations below 100 mcg/mL, the extract showed low toxicity, while in 50% lethality occurring at that dose, that made the selection of the concentrations that can be safely used. The formulated gel was made out of carbomer as the gelling agent, glycerin and propylene glycol as humectants, distilled water as the base, triethanolamine for pH adjustment, and methylparaben as the preservative. The gel's physical properties were within acceptable ranges: the pH 7.68±0.038), viscosity (50,414.67±12.66 cP), and turbidity (31.67±23.18 NTU), it shows an ensuring stability and compatibility for topical use. The anti-inflammatory activity was evaluated through the Egg Albumin Denaturation Assay. It showed a dose-dependent inhibition of the protein denaturation of the forumlated gel. The four extract concentrations achieved 62.66% (25%), 78.96% (50%), 96.14% (75%), and 95.74% (100%) inhibition. The 75% concentration yielded the highest and most consistent anti-inflammatory effect. Thus, the statistical analysis validated the significance of these results, suggesting that the formulated gel may serve as an effective alternative to standard anti-inflammatory drugs. author Batutay, Reign Deniela C. author Beltran, Leilord M. author Comodas, Athena Brittany Cates E. author Navarro, Alyssa Mae B. lcc TH EAC Cavite-Thesis 0 100702 100702 0 0 lcc 0 0 CAVITE CAVITE EAC Cavite-Thesis 2026-11-10 0 T PHAR F67 2025 ML-TH2823 2026-11-10 14:26:02 2026-11-10 TH