000			02850nam a22002537a 4500
003			OSt
005			20261104143944.0
008			261104s2025 |||||||| |||| 00| 0 eng d
050			_aT PHAR _bE34 2025
100	1		_aH.Arief, Emman M.
245	1	0	_aIn vitro antibacterial activity of eggplant (solanum melongena) peel extract in ointment formulation against staphylococcus aureus / _cEmman M. H.Arief, Mubarak M. Lomabao, Rachel R. Martinez, Khea T. Melchor, and Francheska R. Señires.
264			_aEAC Cavite : _bSchool of Pharmacy, _c2025.
300			_a165 pages ; _c28 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references
520			_aThe study confirmed that eggplant (Solanum melongena) peel has antibacterial activity against Staphylococcus aureus and can be formulated into a stable topical ointment, supporting its potential as a sustainable alternative antibacterial agent. Further studies are recommended to quantify active compounds, evaluate broader antimicrobial activity and assess stability, safety, and in vitro efficacy. The eggplant peel extract was obtained through 70% ethanol maceration and concentration after which it underwent both phytochemical screening and organoleptic evaluation. Toxicity and the EDso for the extracts were determined using the brine shrimp lethality assay and probit analysis. Antibacterial activity against Staphylococcus aureus for both the extract and the formulated ointment was tested using the agar well diffusion method with the positive control being mupirocin and the negative control being the untreated ointment base. Quality control tests were performed on the physical properties of the resulting ointment. The Brine Shrimp Lethality Assay (BSLA) was performed to compare the toxicity and effective dose concentration for the tested samples. For each selected sample, the median effective dose (EDso) was calculated using probit analysis. Results obtained from BSLA indicated that the eggplant peel extract contained bioactive phytochemicals that were particularly abundant in phenolic compounds and flavonoids, which showed evidence of antibacterial activity against Staphylococcus aureus based on the presence of clear zones of inhibition. Data collected on the formulated eggplant peel ointment also indicated significant isolates were retained in the eggplant material after topical application, as the antibacterial activity of the eggplant peel ointment was similar to that of mupirocin at higher concentrations and was not statistically different (= 0.05).
700	1		_4author _aLomabao, Mubarak M.
700	1		_4author _aMartinez, Rachel R.
700	1		_4author _aMelchor, Khea T.
700	1		_4author _aSeñires, Francheska R.
942			_2lcc _cTH _kEAC Cavite-Thesis _n0
999			_c100673 _d100673