000			02718nam a22002657a 4500
003			OSt
005			20261110142554.0
008			261110s2025 |||||||| |||| 00| 0 eng d
050			_aT PHAR _bF67 2025
100	1		_aAbril, John Elcid L.
245	1	0	_aFormulation of anti-inflammatory gel from celery (apium graveolens) leaves and stalk extract tested through egg albumin denaturation assay / _cJohn Elcid L. Abril, Reign Deniela C. Batutay, Leilord M. Beltran, Athena Brittany Cates E. Comodas, and Alyssa Mae B. Navarro.
264			_aEAC Cavite : _bSchool of Pharmacy, _c2025.
300			_axiii, 109 pages ; _c28 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
500			_aExperimental research
504			_aIncludes bibliographical references
520			_aInflammation is a biological response to harmful stimuli that aims to eliminate pathogens or injury. This study show the effect of celery in an inflammation in the form of gel. The properties found in celery, such as flavonoids and antioxidants, have shown effectiveness in reducing inflammation associated with inflammatory conditions. The toxicity of the celery's extract was assessed using the Brine Shrimp Lethality Assay, it showed a dose-dependent effect, at concentrations below 100 mcg/mL, the extract showed low toxicity, while in 50% lethality occurring at that dose, that made the selection of the concentrations that can be safely used. The formulated gel was made out of carbomer as the gelling agent, glycerin and propylene glycol as humectants, distilled water as the base, triethanolamine for pH adjustment, and methylparaben as the preservative. The gel's physical properties were within acceptable ranges: the pH 7.68±0.038), viscosity (50,414.67±12.66 cP), and turbidity (31.67±23.18 NTU), it shows an ensuring stability and compatibility for topical use. The anti-inflammatory activity was evaluated through the Egg Albumin Denaturation Assay. It showed a dose-dependent inhibition of the protein denaturation of the forumlated gel. The four extract concentrations achieved 62.66% (25%), 78.96% (50%), 96.14% (75%), and 95.74% (100%) inhibition. The 75% concentration yielded the highest and most consistent anti-inflammatory effect. Thus, the statistical analysis validated the significance of these results, suggesting that the formulated gel may serve as an effective alternative to standard anti-inflammatory drugs.
700	1		_4author _aBatutay, Reign Deniela C.
700	1		_4author _aBeltran, Leilord M.
700	1		_4author _aComodas, Athena Brittany Cates E.
700	1		_4author _aNavarro, Alyssa Mae B.
942			_2lcc _cTH _kEAC Cavite-Thesis _n0
999			_c100702 _d100702